Ch. Praveen Kumar1, K. Saritha*2
The present research was envisaged to develop valacyclovir hydrochloride mucoadhesieve beads using ion tropic external gelation technique by varying concentrations of sodium alginate and HPMC, with calcium chloride and aluminium chloride as gellant solutions. In this technique various proportions of sodium alginate viz 0.5, 1% w/v, 1.5% w/v and HPMC 0.5%w/v were used with calcium chloride (2%, 4% w/v) and aluminium chloride (4%, 6% w/v) as gellant solutions. After the formulation of mucoadhesieve beads, the beads were separated, washed with distilled water and air dried for 48hrs and the formed beads were filled into capsules. The particle size of alginate beads was performed by SEM. Percentage yield of all the formulations was found to be satisfactory except VC-7, VC-10 which gave percentage yield of less than 25%. The results indicated that the release has been retarded with increase in concentration of sodium alginate with calcium chloride as gellant solution. Hence VC-6 (Sodium alginate 1.5%w/v, HPMC 0.5%w/v with calcium chloride (4%w/v) as gellant solutions) was found to be the best formulation which retarded the drug release for 10 Hrs. The results of these models indicate all mucoadhesive beads filled in capsules follows zero order as “best fit model”. This is due to previously proved fact depending on R2 value obtained from model fitting. Korsemeyer - Peppas release exponent (n) values of valacyclovir hydrochloride beads was found to be 0.63-0.71 indicating anomalous transport (Non-Fickian diffusion).
Extended Release, Mucoadhesive Beads, Valacyclovir etc.