M. Suchitra1*, R.V.S Mounica2, M. Murali2
A series of N-substituted thiazolidinediones were synthesised by N-Acylation of mercaptobenzimidazoles using different substituted benzaldehydes and thiourea. Synthesised compounds TZ01-TZ05 were 5-substituted 2,4 thiazolidinediones with aromatic aldehydes. The compounds of the TZ01-TZO4 showed the characteristic peaks in the IR. Electron impact mass spectral analysis was carried out. The titled compounds were investigated for antimicrobial activity by performing the disc diffusion method to determine the zone of inhibition. The Anticancer studies were performed on 2 randomly selected compounds using MTT Assay. The results indicated that two compounds were found to have significant cytotoxic activity against Hela cell line.
Thiazolidinedione; anti bacterial; anti-fungal; anti-cancer etc.