Abstract

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   IJPIB.,   Volume(2) - Issue(3), 2017 pp 158-164,   DOI:123.10.0

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL THIAZOLIDINEDIONE DERIVATIVES

M. Suchitra1*, R.V.S Mounica2, M. Murali2  

Abstract

A series of N-substituted thiazolidinediones were synthesised by N-Acylation of mercaptobenzimidazoles using different substituted benzaldehydes and thiourea. Synthesised compounds TZ01-TZ05 were  5-substituted 2,4 thiazolidinediones with aromatic aldehydes. The compounds of the TZ01-TZO4 showed the characteristic peaks in the IR. Electron impact mass spectral analysis was carried out. The titled compounds were investigated for antimicrobial activity by performing the disc diffusion method to determine the zone of inhibition. The Anticancer studies were performed on 2 randomly selected compounds using MTT   Assay. The results indicated that two compounds were found to have significant cytotoxic activity against Hela cell line. 

Keywords

Thiazolidinedione; anti bacterial; anti-fungal; anti-cancer etc.

Received
10/04/2017
, Accepted
05/05/2017
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