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  Research Article

Year : 2016 | Volume: 1 | Issue: 5 | Pages: 110-114

HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF CAULIFLOWER LEAVES AGAINST METHOTREXATE INDUCED TOXICITY IN ALBINO RATS

Madathala Sreekanth*, Puligoti Pandu, Suneeta Manukonda, Dasi Jeevan Mani Babu

* Corresponding author

  • Department of Pharmacology, Vikas College of Pharmacy, Vissannapeta, Krishna (Dt), Andhra Pradesh, India

  16/07/2016

  27/07/2016

  29/08/2016

  10/09/2016

  • Madathala Sreekanth*, Puligoti Pandu, Suneeta Manukonda, Dasi Jeevan Mani Babu

    , (2016), HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF CAULIFLOWER LEAVES AGAINST METHOTREXATE INDUCED TOXICITY IN ALBINO RATS. International Journal of Pharmacometrics and Integrated Biosciences, 1(5): 110-114. doi: 0

Abstract

The main purpose of the present study was to evaluate the hepatoprotective activity of ethanolic extract of cauliflower leaves against a rat model of Methotrexate induced hepatotoxicity. In this study the hepatoprotective activity of ethanolic extract of cauliflower leaves (EECL) was determined by estimating the serum parameters like AST, ALT, ALP, bilirubin, cholesterol, triglycerides and total serum proteins. The preliminary pytochemical studies revealed the presence of phytoconstituents like alkaloids, flavonoids, steroids, carbohydrates, proteins, tannins, glycosides, saponins, thiols, phenols, triterpenoids, and purins. Silymarin and EELC 200 and 400 mg/kg when administered to rats exhibited protection against Methotrexate induced hepatotoxicity as manifested by the reduction in toxin mediated rise in serum enzymes (AST, ALT, ALP, bilirubin, cholesterol and triglycerides) and increased TP levels. The histopathological studies also revelaed the preservation of liver integrity in treated groups.

Keywords

Hepatoprotective, Hepatotoxicity, Cauliflower, Methotrexate etc