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  Research Article

Year : 2016 | Volume: 1 | Issue: 4 | Pages: 101-104

SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES

Jayakumar. A, Bhageeradha Reddy.E*, Kavitha. M, Harika. S, Viswanatha Reddy. SM

* Corresponding author

  • Ratnam Institute of Pharmacy, Pidthapolur (V), Muthkur (M), Nellore-524346, Andhra Pradesh, India

  17/06/2016

  23/06/2016

  01/07/2016

  10/07/2016

  • Jayakumar. A, Bhageeradha Reddy.E*, Kavitha. M, Harika. S, Viswanatha Reddy. SM

    , (2016), SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES. International Journal of Pharmacometrics and Integrated Biosciences, 1(4): 101-104. doi: 0

Abstract

In the present research O-Phenylenediamine used as a starting material and reacted with five different carboxylic acid derivatives. The product thus formed reacted with P-aminoacetophenone leading to the formation of five benzimidazole derivatives (BD-1 to BD-5). The structures of the synthesized compounds were confirmed by IR & Mass spectral analysis and they were evaluated for their antibacterial and antifungal activities. The antibacterial activities of synthesized compounds were screened against both gram positive S .aureus and gram negative E. coli by agar cup-plate method using ciprofloxacin as standard drug. The antifungal activities of synthesized compounds were screened against Candida albicans by agar cup-plate method using ketaconazole as standard drug. Results revealed that BD-4 and BD-5 showed good antibacterial & antifungal activity.

Keywords

O-phenylene diamine, Benzimidazole, Antibacterial, Antifungal etc