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  Research Article

Year : 2016 | Volume: 1 | Issue: 4 | Pages: 81-86

FORMULATION AND EVALUATION OF AMLODIPINE FLOATING MICRO BEADS

Ramesh Y, Farheen Sd*, Praveena G, Leela gayathri B, Yasmin Sk, Raj Kumar K

* Corresponding author

  • Ratnam Institute of Pharmacy, Pidthapolur (V), Muthkur (M), Nellore-524346, Andhra Pradesh, India

  28/05/2016

  10/06/2016

  25/06/2016

  10/07/2016

  • Ramesh Y, Farheen Sd*, Praveena G, Leela gayathri B, Yasmin Sk, Raj Kumar K

    , (2016), FORMULATION AND EVALUATION OF AMLODIPINE FLOATING MICRO BEADS . International Journal of Pharmacometrics and Integrated Biosciences, 1(4): 81-86. doi: 0

Abstract

The present research explains the preparation and evaluation of Amlodipine floating micro beads by iontotropic external gelation technique. Pre formulation studies like FT-IR and Differential Scanning Calorimetry (DSC) confirmed that no chemical interaction took place during encapsulation process. Surface Morphology of the prepared floating micro beads were characterized by scanning electron microscopy. Six formulations (FMB-1 to FMB-6) were prepared and evaluated for various physic chemical properties.  Pre compressional parameters like Angle of repose, Hausner’s Ratio, Carr’s Index, Bulk density, tapped density etc were performed and the result shows excellent flow property. Post compressional parameters like the Percentage drug content, Entrapment efficiency, Percentage Yield, Swelling studies and In vitro dissolution studies were evaluated. The swelling Index of Amlodipine containing sodium alginate beads was found to be high in FMB-6 with 86.5%. Entrapment efficiency was in range of 15 to 88%. In-vitro studies revealed that 95% of drug released within 1Hour 45 min from FMB-6, which was found to be best among all the formulations. 

Keywords

Amlodipine, Micro beads, Ionotropic gelation, Entrapment efficiency, In Vitro dissolution etc